Cannabidiolic Acid, A Major Cannabinoid In Fiber-Type Cannabis, Is An Inhibitor Of Mda-Mb-231 Breast Cancer Cell Migration

[Canadense]

http://www.ncbi.nlm.nih.gov/pubmed/22963825

Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.

Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H.

Source

Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan.

Abstract

Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.

[Ganjaman_SP]

CBD-A é CBD ácido, certo?

em outro artigo encontrei THC-A, no caso THC ácido...

neste artigo continha a seguinte informaçao:

THC-A is found in variable quantities in fresh, undried cannabis, but is progressively decarboxylated to THC with drying.

THC-A é encontrado na cannabis fresca, se transforma em THC quando é seca e/ou queimada.

imagino que com o CBD-A deve ser a mesma coisa.

então amigos, a forma "crua" de ingerir cannabis, nao traz os efeitos psicoativos da planta que ja conhecemos, mas traz todos os beneficios medicinais que os componentes da cannabis tem para nos oferecer...como exemplo o RAW Cannabis Juice, que no meu ponto de vista TODOS DEVERIAM TOMAR...consiste em fazer um suco das folhas frescas da cannabis, consumindo altas doses de CBD-A e THC-A.

[menteconsiente]

mas esse CBD-A e THC-A são encontrados nas folhas ou nas flores?

[Aquaponic]

muito bom, tão comprovando o que a gente suspeita....

[Thulle]

Hummm, gostei dessa idéia do suco, vamos fazer uma receita

[black flag]

mas esse CBD-A e THC-A são encontrados nas folhas ou nas flores?

Nem em um, nem em outro, todos os componentes são encontrados na resina que está nas flores e nas folhas.