Previne Perda De Memoria Com Ibuprofeno (Advil)!

[Canadense]

Featured Article

Preventing marijuana-induced memory problems with OTC painkillers New study in Cell suggests that use of medical marijuana could be broadened if patients take NSAIDs like ibuprofen By Mary Beth O'Leary | Posted on 21 November 2013

Share story

In addition to being used as a recreational drug, marijuana has been used for centuries to treat a variety of conditions, from chronic pain to epilepsy. However, its medical value is greatly limited by debilitating side effects. A study published by Elsevier's Cell Press today in the journal Cell has revealed the molecular pathways responsible for marijuana-induced learning and memory problems. The findings suggest that preventing these side effects could be as easy as taking an over-the-counter painkiller.

The signaling pathway that leads to learning and memory impairments induced by marijuana (Credit: Cell, Chen et al)

"Our studies have solved the longtime mystery of how marijuana causes neuronal and memory impairments," said senior study author Dr. Chu Chen, Professor of Otorhinolaryngology and Neuroscience at Louisiana State University Health Sciences Center. "The results suggest that the use of medical marijuana could be broadened if patients concurrently take a nonsteroidal anti-inflammatory drug such as ibuprofen."

The main active ingredient in marijuana is Δ 9-tetrahydrocannabinol (Δ9-THC), and drugs based on this compound have been approved by the Food and Drug Administration (FDA) to treat nausea and vomiting in chemotherapy patients. But these drugs have not been approved for a wider range of conditions, in part because of Δ9-THC-induced side effects. Moreover, there are no effective FDA-approved treatments for these side effects because, until now, little was known about the molecular pathways underlying these impairments.

In the new study, Chen and his team discovered that Δ9-THC treatment caused an increase in levels of an enzyme called cyclooxygenase-2 (COX-2) in the mouse hippocampus, a brain region involved in learning and memory. Drugs or genetic techniques that reduced COX-2 levels in mice prevented memory problems and neuronal abnormalities caused by repeated Δ9-THC exposure. Because COX-2 is inhibited by over-the-counter painkillers such as ibuprofen, the findings suggest an easy strategy to prevent the side effects of marijuana.

Chu Chen, PhD

Our studies have solved the longtime mystery of how marijuana causes neuronal and memory impairments.

The researchers also discovered that Δ9-THC treatment reduced neuronal damage in a mouse model of Alzheimer's disease, and this beneficial effect persisted when the animals were simultaneously treated with a COX-2 inhibitor.

"There are no effective medications currently available for preventing and treating Alzheimer's disease or halting disease progression," Dr. Chen said. "Our results suggest that the unwanted side effects of cannabis could be eliminated or reduced, while retaining its beneficial effects, by administering a COX-2 inhibitor along with Δ9-THC for the treatment of intractable medical conditions such as Alzheimer's disease."

[DougTorquato]

whataaaaaaafuuuuuuuck mannnnnn!!! this is amazing!!

[HST]

Essa merda causa de 150.000 a 275.000 mortes por ano, prefiro esquecer algumas coisas a tomar isso daí.

[dine]

Carái, véi. Acabei de fazer uso dessa merda e não sabia q causava morte. O dentista receitou. Até agora tudo bem...

[Hots]

Muito interessante!

Mas agora, não sei se entendi direito, é para tomar o remédio apenas alguns minutos antes de fazer uso da Cannabis? ou isso acaba virando um tratamento diário?

Se algum conseguir me responder agradeço muito!

Att

[flokinhos]

Será que a indústria farmaceutica está usando como estratégia pegar uma carona nos benefícios da cannabis medicinal e agora irão surgir vários estudos como este?

[ntfsmount]

Vou perguntar para o Jose Celso se ele precisa disso pra lembrar das coisas...kkkk

[biscoito71]

Carái, véi. Acabei de fazer uso dessa merda e não sabia q causava morte. O dentista receitou. Até agora tudo bem...

não tem muito pra onde correr, paracetamol é hepatotóxico, dipirona causa agranulocitose, outros causam infartos, úlcera....

é complicado, mas fazer o quê? deixar com dor não dá né, seu dentista receitou corretamente.

[biscoito71]

se ibuprofeno previne perda de memória.

já tomou o seu hj cabelo? eu me mediquei foi de outro jeito rs

[dine]

não tem muito pra onde correr, paracetamol é hepatotóxico, dipirona causa agranulocitose, outros causam infartos, úlcera....

é complicado, mas fazer o quê? deixar com dor não dá né, seu dentista receitou corretamente.

Valeu, biscoito71.

Pior q não tomo essas drogas. O dentista me passou por telefone e eu comprei pensando q era só antiinflamatório. Mas é analgésico tb, e pra dor q estava acho q novalgina mesmo dava pro gasto.

Mas foi legal esse papo aqui, q é mais um pra minha lista negra.

[Canadense]

Eu tomo ibuprofeno diariamente, ate msm antes de saber isso.

1600 mg.

[Hots]

Mas vc toma pq

Eu tomo ibuprofeno diariamente, ate msm antes de saber isso.

1600 mg.

Mas por qual motivo vc toma? Na sua experiência, acha que ajuda mesmo? Toma quantas cápsulas por dia?

Att